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KMID : 0613820220320050368
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Journal of Life Science
2022 Volume.32 No. 5 p.368 ~ p.374
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Anti-inflammatory and Anti-allergic Effects of Lentinula edodes Extract by UV Irradiation
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Hwang Mi-Sun
Pyo Jae-Sung
Kim Hyun-Jin
Do Sun-Gil
Song Il-Dae
Kim Kang-Min
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Abstract
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In this study, the effects of UV irradiation-enhanced ergocalciferol (vitamin D2) content containing Lentinula edodes extract on inflammation and allergic responses were investigated in vitro. The anti-inflammatory and anti-allergic effects of the mushroom extract were tested by estimating the cytokine secretions, such as TNF-α, IL-6, and IL-1β in LPS-activated macrophages (RAW 264.7), or histamine release in PMA and A23187-activated mast cells (RBL-2H3). Under the condition of macrophage activation with LPS, mushroom extract significantly reduced the secretions of pro-inflammatory cytokines, TNF-α and IL-6, and their mRNA expression also matched the observation. The current mushroom extract also significantly reduced the amount of mast cell degranulation-induced histamine secretion from PMA- and A23187-treated mast cells as well as the reduced secretion of IL-4. These results suggest that mushroom extract, which has increased ergocalciferol content by UV irradiation, inhibits the expression of cytokines in inflammation and allergic reactions; therefore, it can be used effectively for the prevention and treatment of inflammatory and allergic diseases.
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KEYWORD
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Anti-allergy, anti-inflammation, cytokine, Lentinula edodes, vitamin D
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